H-Ile-Pro-Pro-OH
CAS No. : 26001-32-1
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| Cat. No. : | HY-114424 |
| M.Wt: | 325.40 |
| Formula: | C16H27N3O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].
IC50 & Target: IC50: 5 μM (ACE)[2]
In Vitro: Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].
In Vivo: Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].
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