Allura Red AC (Standard)

Allura Red AC (Standard) is an analytical standard of Allura Red AC. This product is intended for research and analytical applications. Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety^[1][2][3]. In Vitro:Allura Red AC (1 pmol/L, 24 h) promotes 5-HT secretion, upregulates TPH1 mRNA expression, and enhances ROS generation in BON cells (EC cells (enterochromaffin cells))^[3]. In Vivo:Allura Red AC (100 ppm, Ad libitum intake for 12 weeks) exacerbates colitis in the DSS-induced colitis C57BL/6 mouse model and enhances inflammation through 5-HT-mediated mechanisms^[3].
Allura Red AC (100 ppm (100 mg of Allura Red AC per 1 kg of diet), Ad libitum intake for 5 weeks) exacerbates colitis in the CD4+CD45RB^hi T cell-induced colitis Rag1^-/- mouse model and promotes T cell-mediated inflammation^[3].
Allura Red AC (500-2000 mg/kg, p.o., single dose) shows no in vivo genotoxic potential in mice^[2].