Larazotide
CAS No. : 258818-34-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $136 | In-stock |
| 25mg | $300 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-106268 |
| M.Wt: | 725.83 |
| Formula: | C32H55N9O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2]. In Vitro: Larazotide (1-100 μM; 5 d) affects Vero cell growth[1]. Larazotide (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively[1]. Larazotide (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells[2]. Larazotide (100 μM; 3 h) inhibits gliadin translocation across Caco-2 monolayers[2]. Larazotide (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells[2]. In Vivo: Larazotide (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice[1].
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