7β-Hydroxy-epi-androsterone
CAS No. : 25848-69-5
(Synonyms: 7β-Hydroxy-EpiA)
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| Cat. No. : | HY-107043 |
| M.Wt: | 306.44 |
| Formula: | C19H30O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].
In Vitro:7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 72 h) inhibits MCF-7 and MDA-MB-231 cell proliferation in the presence of E2 (10 nM)[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) leads to a G0/G1 cell cycle arrest in MCF-7 and MDA-MB-231 cells[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) increases cell apoptosis in the presence of E2 (10 nM) in MCF-7 cells[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 24 h) binds to ERβ and decreases in transactivation in MDA-MB-231 cells[2].
In Vivo:7β-Hydroxy-epi-androsterone (i.p., once a day for 7 days) displays anti-inflammatory effects in rat with DSS-induced colitis[3].
7β-Hydroxy-epi-androsterone (0.1 mg/kg s.c., b.i.d. for 10 days) shows protective effect against inflammatory neurodegeneration and glial cell death in Alzheimer's disease rats[4].
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