Have any questions? [email protected] +86-21-58998590
Structure search

Azoxymethane


CAS No. : 25843-45-2

(Synonyms: AOM)

25843-45-2
Price and Availability of CAS No. : 25843-45-2
Size Price Stock
135 mM * 500 μL in Water $332 In-stock
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-111375
M.Wt: 74.08
Formula: C2H6N2O
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 25843-45-2 :

Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. In Vitro: Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N7-mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes[1]. In Vivo: Azoxymethane can be used to induce colorectal cancer models.

Induction of Colonic
Background
Azoxymethane induces induces G to A transitions and leads to activating mutations in K-ras and β-catenin in colonocytes, ctivation of Wnt signaling by accumulation of beta-catenin is a major mechanism in the azoxymethane-induced colon carcinogenesis model.
Specific Mmodeling Methods
Mice: 20-25 g•Male A/J mice&bull
Administration: 5 mg/kg• i.p.• weekly for 6 weeks
Note
Modeling Indicators
Cellular/tissue level: Induced hyperproliferation and microadenoma formation, Increased the cyclin D1 and COX-2 expression.
Molecular changes: Increased the protein expression of pro-TGF-α, pEGFR, pErbB2, pERK, induces K-ras mutations.
Correlated Product(s): /
Opposite Product(s): Gefitinib (HY-50895)

Your information is safe with us.