Azoxymethane
CAS No. : 25843-45-2
(Synonyms: AOM)
| Size | Price | Stock |
|---|---|---|
| 135 mM * 500 μL in Water | $332 | In-stock |
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| Cat. No. : | HY-111375 |
| M.Wt: | 74.08 |
| Formula: | C2H6N2O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 200 mg/mL |
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.
In Vitro:Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N7-mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes[1].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Azoxymethane can be used to induce colorectal cancer models.
Administration: 5 mg/kg• i.p.• weekly for 6 weeks
Molecular changes: Increased the protein expression of pro-TGF-α, pEGFR, pErbB2, pERK, induces K-ras mutations.
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