A-259745
CAS No. : 256934-83-5
(Synonyms: A-289099)
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| Cat. No. : | HY-101741 |
| M.Wt: | 366.41 |
| Formula: | C21H22N2O4 |
| Purity: | >98 % |
| Solubility: |
A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED50 values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer[1].
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