CL075
CAS No. : 256922-53-9
(Synonyms: 3M002)
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117066 |
| M.Wt: | 243.33 |
| Formula: | C13H13N3S |
| Purity: | >98 % |
| Solubility: | DMSO : 22 mg/mL (ultrasonic;warming) |
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively[1][2][3].
IC50 & Target: TLR8[1]
In Vitro: CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes[1].
CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes[1].
CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells[1].
In Vivo: CL075 (5 μM (0.5 mL); s.c.) activates a mild antigen-specific antibody response in rabbits[1].
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