J-113397
CAS No. : 256640-45-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $560 | In-stock |
| 50mg | $896 | In-stock |
| 100mg | $1520 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-114072 |
| M.Wt: | 399.57 |
| Formula: | C24H37N3O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
J-113397 is the first potent and selective nonpeptidyl ORL1 receptor antagonist (Ki: cloned human ORL1=1.8 nM) without any agonistic effects on other opioid receptors[1]. In Vitro:J-113397 (0-500 nM) inhibits NociceptinNociceptin/orphanin FQ (HY-P0183)-stimulated [35S]GTPγS binding to CHO cells expressing ORL1 (CHO-ORL1) but had no effect on [35S]GTPγS binding by itself[1]. In Vivo:J-113397 (0-30 mg/kg; subcutaneously (s.c.); once) dose-dependently inhibits hyperalgesia elicited by intracerebroventricular (i.c.v.) administration of NociceptinNociceptin/orphanin FQ (HY-P0183) in a tail-flick test with mice[1].
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