Ac2-12
CAS No. : 256447-08-2
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| Cat. No. : | HY-P1099 |
| M.Wt: | 1351.57 |
| Formula: | C63H94N14O17S |
| Purity: | >98 % |
| Solubility: | H2O |
Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].
In Vivo: Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)[1].
Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice[2].
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