CRL-42872
CAS No. : 256385-24-7
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| Cat. No. : | HY-119238 |
| M.Wt: | 539.00 |
| Formula: | C22H27ClN6O6S |
| Purity: | >98 % |
| Solubility: |
CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies[1].
In Vitro:CRL-42872 (1.5×10-8 M - 7×10-5 M; 3 minutes) potently inhibits collagen-induced aggregation of guinea pig platelets with an IC50 of 9.4×10-8 M[1].
CRL-42872 (10-8 M - 5×10-5 M; 3 minutes) inhibits collagen-induced aggregation of human platelets with an IC50 of 1.2×10-7 M[1].
In Vivo:CRL-42872 (10 mg/kg; p.o.; single dose) achieves inhibition of collagen-induced guinea pig platelet aggregation[1].
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