Rivenprost
CAS No. : 256382-08-8
(Synonyms: ONO-4819; ONO-AE1-734)
| Size | Price | Stock |
|---|---|---|
| 2.22 mM * 1 mL in Methyl acetate | $880 | In-stock |
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| Cat. No. : | HY-114974 |
| M.Wt: | 450.59 |
| Formula: | C24H34O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Rivenprost is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects[1][2].
In Vitro:Rivenprost (1 nM–1 μM) stimulates the osteoblast differentiation through upregulation of Runx2 and Osterix, leading to increased bone formation[1].
Rivenprost (1 nM–1 μM) inhibits the adipocytes differentation in bone by downregulating the mRNA expression of PPARγ[1].
In Vivo:Rivenprost (10 μg/kg, s.c. for 5 weeks) increases bone formation and decreases levels of age-dependent adipocytes in Sprague-Dawley rats[1].
Rivenprost (0.2 mg/kg, i.p., single dosage) exhibits hepatoprotective efficacy towards GalN-/LPS-induced liver injury in wistar rats through inflammatory cytokines such as TNF-α[2].
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