BAY 41-2272
CAS No. : 256376-24-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $168 | In-stock |
| 25mg | $348 | In-stock |
| 50mg | $552 | In-stock |
| 100mg | $984 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12376 |
| M.Wt: | 360.39 |
| Formula: | C20H17FN6 |
| Purity: | >98 % |
| Solubility: | DMSO : 17.5 mg/mL (ultrasonic) |
BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research[1][2].
In Vitro:BAY 41-2272 (10 μM; 15 min) increases cGMP levels by itself and synergizes with the NO donor SNP (100 μΜ) in A7r5 rat aortic smooth muscle cells[1].
In Vivo:BAY 41-2272 (0.3-3 mg/kg; p.o.; single dose; monitored for 12 h) has inhibitory effect in hypertensive dog[2].
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