Bruceine A
CAS No. : 25514-31-2
(Synonyms: Dihydrobrusatol; NSC310616)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $600 | In-stock |
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| Cat. No. : | HY-N0841 |
| M.Wt: | 522.54 |
| Formula: | C26H34O11 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 25 mg/mL |
Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of parasites, NF-κB, and PFKFB4 (Kd: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research[1][2][3][4][5].
In Vitro:Bruceine A (6.25-100 nM/0.08-20 μM, 24-72 h) inhibits the viability of pancreatic cancer cell lines MIA PaCa-2, SW1990, PANC-1 and AsPC-1 cells in a time- and dose-dependent manner[1].
Bruceine A (12.5-50 nM, 24 h) increases the percentage of MIA PaCa-2 cells in the G1 phase[1].
Bruceine A (12.5-50 nM, 24 h) induces apoptosis of MIA PaCa-2 cells in a dose-dependent manner[1].
Bruceine A (12.5-50 nM, 24 h) inhibits the mRNA expression level of PFKFB4 in MIA PaCa-2 cells[1].
Bruceine A (30-120 nM/0.3-1.2 μM, 24-48 h) inhibits the viability of MDA-MB-231 (IC50: 78.4 nM) and 4T1 (IC50: 524.6 nM) cells in triple negative breast cancer (TNBC) cell lines[2].
Bruceine A (7.5-30 nM/150-450 nM, 48 h) causes G0-G1 cell cycle arrest in MDA-MB-231 and 4T1 cells[2].
Bruceine A (60-240 nM/0.6-2.4 μM, 48 h) induces apoptosis (58.37% and 56.21%) in MDA-MB-231 and 4T1 cells in a dose-dependent manner[2].
Bruceine A (30-120 nM/0.3-1.2 μM, 24 h) inhibits the migration of MDA-MB-231 and 4T1 cells in a concentration-dependent manner[2].
Bruceine A (72 h) inhibits the activity of Entamoeba histolytica (IC50: 222.0 nM), Plasmodium falciparum (IC50: 21.0 nM), Babesia gibbsii (IC50: 7.7 nM), and Trypanosoma evansi (IC50: 2.9 nM)[3].
Bruceine A (2 h) inhibits the activity of NF-κB in Hela cells (IC50: 5.3 μg/mL)[4].
Bruceine A activates the p38α MAPK signaling pathway in MIA PaCa-2 cells[5].
In Vivo:Bruceine A (0.02-0.5 mg/kg, i.v., once every day for 10 d) exhibits antitumor activity in mice with the BALB/c nude mouse pancreatic cancer model[1][4].
Bruceine A (2-4 mg/kg, i.p., once every day for 2 weeks) has antitumor activity in mice with 4T1 xenograft tumor model[2].
Bruceine A (2-4 mg/kg, i.p., once every day for 17 d) inhibits lung metastasis in mice with 4T1-luc breast cancer lung metastasis model[2].
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