ZD6021
CAS No. : 255049-08-2
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| Cat. No. : | HY-118378 |
| M.Wt: | 632.64 |
| Formula: | C35H35Cl2N3O2S |
| Purity: | >98 % |
| Solubility: |
ZD6021 is an orally active Neurokinin 1 Receptor antagonist, with Ki values of 0.12 nM for NK1 and 0.62 nM for NK2. At a concentration of 100 nM, ZD6021 has a pKB value of 8.9 for human pulmonary artery NK1 receptors, and a pKB value of 7.3 for human bronchial NK2 receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED50 of 0.5 mg/kg, and also decreases NK2 mediated bronchoconstriction, with an ED50 of 13 mg/kg[1].
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