Ataciguat
CAS No. : 254877-67-3
(Synonyms: HMR-1766)
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $100 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $730 | In-stock |
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| Cat. No. : | HY-17500 |
| M.Wt: | 576.49 |
| Formula: | C21H19Cl2N3O6S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3].
IC50 & Target: soluble guanylate cyclase[1]
In Vitro: Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings[2].
Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells[2].
Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol[3].
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