IDN-7314

IDN-7314 is a pan-Caspase inhibitor with an IC₅₀ of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury^[1][2]. In Vitro:IDN-7314 is a potent pan-caspase inhibitor, with IC₅₀ values of 0.2-7 nM for all tested caspases^[1].
IDN-7314 (100 nM) abolishes Jo2-induced caspase-3/7 activity and significantly reduces hepatocyte tissue factor procoagulant activity and release of tissue factor-positive microvesicles^[2].
In Vivo:IDN-7314 (10 mg/kg; i.p.) potently inhibits galactosamine-induced hepatocellular apoptosis and caspase-3 activation in female Sprague-Dawley rats, with 76-71% reductions in apoptotic hepatocytes depending on treatment schedule, but only modestly reduces plasma ALT levels and oncotic cell death in this model^[1].
IDN-7314 (3 mg/kg; i.p.; single dose) inhibits caspase activation, prevents procoagulant changes, and reduces hepatocellular injury in Mus musculus (mice) with Fas-induced apoptotic liver injury^[2]. Wait, no-wait, the original text uses "mice" not the Latin name. Let me correct that to follow the original content strictly:\n\nIDN-7314 (3 mg/kg; i.p.; single dose) inhibits caspase activation, prevents procoagulant changes, and reduces hepatocellular injury in mice with Fas-induced apoptotic liver injury^[2].\n\nWait, rechecking: "Fas" is an English target name, so it should be bold. Citations get superscript. No other entities here-no Latin species name used (the text says "mice" not the Latin binomial, so we don't alter that), no gene symbols, chemical formulas, etc. That's correct.