Bovinic acid
CAS No. : 2540-56-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $90 | In-stock |
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| Cat. No. : | HY-113162 |
| M.Wt: | 280.45 |
| Formula: | C18H32O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Bovinic acid is an orally active anti-inflammatory agent. Bovinic acid inhibits oxidative stress and ferroptosis by regulating the Keap1-Nrf2 signaling pathway. Bovinic acid exerts hepatoprotective effects against alcohol-associated liver disease. Bovinic acid can be used for the research of alcohol-associated liver disease[1].
In Vitro:Bovinic acid (0.5-50 μM) inhibits oxidative stress and ferroptosis in HepG2 cells treated with ethanol/tBHP (reducing the levels of ROS, MDA, and Fe2+, and enhancing the activities of SOD and GSH)[1].
Bovinic acid activates the Keap1-Nrf2 antioxidant signaling pathway in ethanol/tBHP-treated HepG2 cells by downregulating Keap1 and upregulating Nrf2 and HMOX1[1].
Bovinic acid inhibits TFRC-mediated iron uptake in ethanol/tBHP-treated HepG2 cells by downregulating TFRC mRNA expression[1].
In Vivo:Bovinic acid (0.1 g/kg; i.g.; daily; 10 days) alleviates ethanol-induced alcohol-related liver disease in male C57BL/6J mice[1].
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