Phenazine-1-carboxylic acid

Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation^[1][2][3][4]. In Vitro:Phenazine-1-carboxylic acid (10-100 µM, 24 and 48 hours) can effectively inhibit the proliferation of DU145 cells in a time- and dose-dependent manner^[2].
Phenazine-1-carboxylic acid (50 µM, 24 hours) can induce apoptosis in DU145 cells through ROS generation and mitochondrial apoptosis pathways^[2].
Phenazine-1-carboxylic acid (50 µM, 36 hours) can upregulate IL-8 and ICAM-1 expression, inhibit RANTES and MCP-1 release, and has potential immunomodulatory activity^[3].
In Vivo:Phenazine-1-carboxylic acid (2 and 3 µg/mL, added through E3 medium, single dose) significantly prevented V. anguillarum infection in zebrafish embryos^[4].