PX-316
CAS No. : 253440-95-8
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| Cat. No. : | HY-119134 |
| M.Wt: | 584.72 |
| Formula: | C28H57O10P |
| Purity: | >98 % |
| Solubility: |
PX-316 is an Akt inhibitor. PX-316 can phosphorylate Akt, but does not inhibit the phosphorylation of PDK1 or PKC. PX-316 uniquely increases the expression of a group of mitochondrial-related genes. PX-316 can be used for the study of colon cancer and breast cancer[1].
In Vitro:PX-316 (0-15 μM, 2 h) specifically inhibits Akt (IC50 = 1.7 μM) activation in HT-29 human colon cancer cells without affecting upstream kinase PDK1 or related kinase PKC[1].
PX-316 (0.5-20 μM, 3 days) inhibits the proliferation of MCF-7 and HT-29 cells[1].
In Vivo:PX-316 (37.5-150 mg/kg, i.p., once) effectively inhibits the Akt signaling pathway and its downstream targets in HT-29 cells xenograft mice, and the inhibitory effect is maintained even after multiple administrations[1].
PX-316 (50-150 mg/kg, i.p., once for 4-10 days) demonstrates dose- and regimen-dependent antitumor activity in two different mice xenograft models of human tumors (MCF-7 and HT-29)[1].
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- Cat. No.:
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