BMS-262084
CAS No. : 253174-92-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $580 | In-stock |
| 10mg | $1050 | In-stock |
| 25mg | $2250 | In-stock |
| 50mg | $3600 | In-stock |
| 100mg | $5900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-118969 |
| M.Wt: | 425.48 |
| Formula: | C18H31N7O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects[1][2].
IC50 & Target:IC50: 2.8 nM (factor XIa), 5 nM (tryptase)[1]
In Vitro: BMS-262084 shows more than 70-fold selectivity for human factor XIa (IC50=2.8 nM) over tryptase, trypsin, urokinase, plasma kallikrein, plasmin, yhrombin (factor IIa) and Factor IXa (IC50=0.005, 0.05, 0.542, 0.55, 1.7,10.5, and 17.4 μM, respectively)[1].
BMS-262084 (1-100 μM) doubles the activated thromboplastin time in human and rat plasma at 0.14 and 2.2 μM, respectively[1].
In Vivo: BMS-262084 (2-12 mg/kg + 2-12 mg/kg/h; i.v.) reduces carotid artery thrombus weight and improves both vessel patency and integrated flow in rats[1].
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