Ispronicline
CAS No. : 252870-53-4
(Synonyms: TC-1734; ACD3480)
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $270 | In-stock |
| 100mg | $400 | In-stock |
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| Cat. No. : | HY-10063 |
| M.Wt: | 234.34 |
| Formula: | C14H22N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2]. In Vivo: Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain[1]. Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d)[2].
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