Veldoreotide
CAS No. : 252845-37-7
(Synonyms: DG3173; PTR-3173)
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| Cat. No. : | HY-P0024 |
| M.Wt: | 1123.30 |
| Formula: | C60H74N12O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Veldoreotide (DG3173) a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1]
IC50 & Target:EC50: 37.6 ± 4.5 nM (GIRK2-SST2); 31.3 ± 14.4 nM (GIRK2-SST4), 10.5 ± 3.4 nM (GIRK2-SST5)[1]
IC50: 0.49 nM (GH)[2]
In Vitro:Veldoreotide stimulates the SST2, SST4, and SST5 receptors with high potency and efficacy in the HEK293 cells, co-expressing these receptors with the GIRK2 channels; EC50s of 37.6 ± 4.5 nM, 31.3 ± 14.4 nM and 10.5 ± 3.4 nM for GIRK2-SST2, GIRK2-SST4 and GIRK2-SST5, respectively[1].
Veldoreotide (10 μM; 24 h) inhibits SST4-expressing BON-1 cells[1].
Veldoreotide (DG3173) (100 nM or 1 μM; 6 h) inhibits GH secreation in adenomas with an IC50 of 0.49 nM[2].
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