Posizolid
CAS No. : 252260-02-9
(Synonyms: AZD2563; AZD5847)
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| Cat. No. : | HY-15993 |
| M.Wt: | 465.40 |
| Formula: | C21H21F2N3O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity[1].
IC50 & Target: Posizolid shows very good anti-mycobacterial activity[1].
In Vitro: Posizolid is determined the activity of against 250 highly resistant pneumococci and 267 drug-susceptible isolates. Posizolid MICs for 50 and 90% of the strains tested are 1 and 2 μg/ml and 0.5 and 1 μg/ml, respectively, for the two isolate groups[2].
In Vivo: AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule.
In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h[3].
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