AZD7545
CAS No. : 252017-04-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $113 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $620 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16082 |
| M.Wt: | 478.87 |
| Formula: | C19H18ClF3N2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 46 mg/mL |
AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC50s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively[1].
IC50 & Target: IC50: 6.4 nM (PDHK2), 36.8 nM (PDHK1)[1]
In Vitro: AZD7545 (10 μM; 90 hours for BRAFV600E human melanoma cells and 120 hours for NRAS mut human melanoma cells) specifically suppresses growth of cells harboring BRAF and NRAS mutations as well as in inhibitor-resistant human melanoma[2].
In Vivo: A single dose of AZD7545 (Oral administration; 10 mg/kg once a day (08:00 h) or Twice a day (08:00 and 18:00 h); for 7 days) to Wistar rats increases the proportion of liver PDH in its active, dephosphorylated form in a dose-related manner. A single dose of 10 mg/kg also significantly elevates muscle PDH activity in obese Zucker (fa/fa) rats[3].
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