ICAM-1-IN-1
CAS No. : 251994-14-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $238 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1530 | In-stock |
| 50mg | $2448 | In-stock |
| 100mg | $3672 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00003 |
| M.Wt: | 363.23 |
| Formula: | C15H11BrN2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 135 mg/mL |
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively. IC50 & Target: IC50: 7 nM (E-selectin), 5 nM (ICAM-1)[1] In Vivo: ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed[1].
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