A-205804
CAS No. : 251992-66-2
| Size | Price | Stock |
|---|---|---|
| 100mg | $75 | In-stock |
| 250mg | $157 | In-stock |
| 1g | $563 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-100226 |
| M.Wt: | 300.41 |
| Formula: | C15H12N2OS2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases[1].
IC50 & Target: IC50: 20 nM (E-selectin), 25 nM (ICAM-1)[1]
In Vitro: A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of 152 μM[1].
A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system[1].
In Vivo: A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat[1].
A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice[2].
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