Derenofylline
CAS No. : 251945-92-3
(Synonyms: SLV 320)
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $155 | In-stock |
| 50mg | $265 | In-stock |
| 100mg | $385 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14858 |
| M.Wt: | 308.38 |
| Formula: | C18H20N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
In Vitro: Derenofylline (100 μM, 72 h) inhibits TGF-β1-induced myofibroblast transformation without affecting the cell viability[2].
In Vivo: Derenofylline (0.3-10 mg/kg, oral administration) suppresses adenosine-induced bradycardia in rats[1].
Derenofylline (10 mg/kg/d, oral administration, 12 weeks) reduces myocardial fibrosis in 5/6 nephrectomy rats without affecting blood pressure[1].
Derenofylline (0.1-5mg/kg, intravenous injection) causes no major haemodynamic effects (heart rate and blood pressure)[1].
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