GGTI-2154
CAS No. : 251577-10-3
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| Cat. No. : | HY-16229 |
| M.Wt: | 420.50 |
| Formula: | C24H28N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GGTI-2154 is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 can be used for the research of cancer[1][2].
IC50 & Target: IC50: 21 nM (GGTase I)[1]
In Vitro: GGTI-2154 inhibits the transfer of geranylgeranyl from [3H]GGPP to H-Ras CVLL, with an IC50 of 21 nM[1].
In Vivo: GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice[2].
GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60%[1].
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