SU16f
CAS No. : 251356-45-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $500 | In-stock |
| 100mg | $700 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-108628 |
| M.Wt: | 386.44 |
| Formula: | C24H22N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
SU16f is a potent and selective PDGFRβ inhibitor with IC50s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, VEGF-R2, FGF-R1, respectively[1]. Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration[2].
In Vitro:SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation[1].
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM [1].
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