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|---|---|---|
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| 500 mg | Get quote | |
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| Cat. No. : | HY-P1164 |
| M.Wt: | 1388.57 |
| Formula: | C64H85N13O18S2 |
| Purity: | >98 % |
| Solubility: | H2O |
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14. IC50 & Target: GPR14[1] In Vitro: Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1]. In Vivo: Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].
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