Urotensin II (114-124), human


CAS No. : 251293-28-4

251293-28-4
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Cat. No. : HY-P1164
M.Wt: 1388.57
Formula: C64H85N13O18S2
Purity: >98 %
Solubility: H2O
Introduction of 251293-28-4 :

Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14. IC50 & Target: GPR14[1] In Vitro: Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1]. In Vivo: Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

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