Justicidin A
CAS No. : 25001-57-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-117078 |
| M.Wt: | 394.37 |
| Formula: | C22H18O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer[1].
In Vitro:justicidin A (0-2.5 μM; 6 days) inhibits cell growth in colorectal cancer cells with IC50 values of 0.110, 0.400, 0.020, 1.540 and 0.004 μM for HT-29, HCT 116, SiHa, MCF7 and T24 cells, respectively[1].
justicidin A (0.75 and 5 μM; 0-72 h) induces apoptosis in colorectal cancer cells[1].
justicidin A (0.75 and 5 μM; 0-72 h) induces the cleavage of caspases and their target proteins in human colorectal cancer cells[1].
justicidin A (0.75 and 5 μM; 0-72 h) damages mitochondria and releases cyto c and Smac from mitochondria[1].
justicidin A (0.75 and 5 μM; 0-96 h) decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria[1].
In Vivo:justicidin A (6.2 mg/kg; p.o.; daily, for 56 days) suppresses the growth of human colorectal cancer cells in mice[1].
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