4-Aminobenzamidine (dihydrochloride)

4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active urokinase type plasminogen activator (uPA) inhibitor (K_i=82 μM). 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study^[1][2][3][4]. IC50 & Target:Trypsin^[1]
K_i: 82 μM (uPA)^[1] In Vitro:4-Aminobenzamidine dihydrochloride causes a dose-dependent inhibition of uPA activity in DU145 cells^[2].
4-Aminobenzamidine dihydrochloride has an anti-proliferative effect in DU145 cells. 4-Aminobenzamidine (100-250 μM, 24 h) abolishes rat hepatocyte proliferation induced by plasminogen and EGF^[2][3].
4-Aminobenzamidine (1-100 μM) dihydrochloride induces a dose-dependent vasodilator effect in intact endothelium aortic rings from Wistar and SHR^[4].
4-Aminobenzamidine (1 nM) dihydrochloride evokes coronary vasodilation in the isolated hearts of Wistar rats and SHR^[4].
In Vivo:4-Aminobenzamidine (250 mg/kg; p.o.; 23 days) dihydrochloride shows a clear decrease in tumor-growth rate in DU145 xenograft mice^[2].
4-Aminobenzamidine (0.01-10 μg/kg; i.v.; 5-min interval between each dose injection. 1mg/kg; p.o.; daily for 60 days) dihydrochloride prevents the progress of hypertension, improved endothelial function, and attenuated the cardiac remodeling in hypertensive rats^[4].