Azaphen

Azaphen (Pipofezin) is an orally active serotonin reuptake inhibitor. Azaphen potentiates sympathomimetic compound effects. Azaphen can be used for the research of depressive states^[1][2]. In Vivo:Azaphen (10-25 mg/kg; single dose) significantly prolongs Phenamine (HY-W016477)-induced stereotypic behavioral reactions in white rats, with mean durations increased to 105 min and 147 min, respectively^[1].
Azaphen (25-50 mg/kg; s.c.; single dose) significantly increases the group toxicity of Phenamine in white mice, inducing up to 95% mortality when combined with 10 mg/kg Phenamine, while also enhancing Phenamine-induced motor activity and hyperthermia^[1].
Azaphen (25-50 mg/kg; s.c.; single dose) antagonizes Reserpine (HY-N0480)-induced depression effects in white mice, reducing blepharoptosis to 2.6 points and 2.3 points, respectively, while decreasing hypothermia^[1].
Azaphen (25-50 mg/kg; s.c.; single dose) antagonizes Tetrabenazine (HY-B0590)-induced depression effects in white mice, reducing blepharoptosis to 2.3 points and 1.1 points, respectively, while decreasing hypothermia and catalepsy^[1].
Azaphen (25 mg/kg; p.o.; single dose) significantly increases active escape attempts in the mouse water escape test, with a mean of 48 water wheel rotations per mouse over 6 minutes^[2].
Azaphen (10-25 mg/kg; p.o.; single dose) exhibits antireserpine activity in mice, with a statistically significant reduction in Reserpine-induced blepharoptosis at 25 mg/kg to a rate of 2.7^[2].
Azaphen (25 mg/kg; p.o.; single dose) significantly reduces anxiety-related inhibition in mice exposed to electric irritation, increasing plate crossings to 10.5 over 2 minutes^[2].
Azaphen (25 mg/kg; p.o.; single dose) significantly reduces aggressive behavior in mice, decreasing fight counts to 8 (isolation-induced) and 9 (electric irritation-induced)^[2].
Azaphen (10 mg/kg; p.o.; single dose) significantly reduces amnesia in rats, increasing passive avoidance conditioned reflex retention to 30% (electroshock-induced) and 50% (Scopolamine (HY-N0296)-induced)^[2].
Azaphen (10 mg/kg; p.o.; daily; 4 days) does not produce a statistically significant restoration of ethanol-impaired active avoidance conditioned reflex learning in rats^[2].
Azaphen (25-100 mg/kg; p.o.; single dose) exhibits dose-dependent antihypoxic activity in mice, significantly increasing survival time in hypoxic hypoxia at 50 mg/kg (37 min) and 100 mg/kg (44 min), and in hemic hypoxia at 25 mg/kg (22 min) and 50 mg/kg (21 min)^[2].
Azaphen (25 mg/kg; p.o.; daily; 5 days) produces a pronounced protective effect in rats with circulatory hypoxia, resulting in 100% survival over 5 days^[2].
Azaphen (5-25 mg/kg; p.o.; single dose) increases physical endurance in mice swimming with a load^[2].
Azaphen (25 mg/kg; p.o.; single dose) does not produce a statistically significant change in mouse motor activity^[2].