KRN2
CAS No. : 248260-75-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $630 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112125 |
| M.Wt: | 479.93 |
| Formula: | C27H23ClFNO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis[1].
IC50 & Target:IC50: 100 nM (NFAT5)[1].
In Vitro: KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions[1].
KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1[1].
In Vivo: KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role[1].
KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration[1].
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