GW 9578
CAS No. : 247923-29-1
| Size | Price | Stock |
|---|---|---|
| 20.30 mM * 50 μL in Methyl acetate | $70 | Get quote |
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| Cat. No. : | HY-117196 |
| M.Wt: | 492.62 |
| Formula: | C26H34F2N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].
In Vitro: GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.005, 1.5, 2.6 μm, respectively. GW9578 exhibits activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.05, 1, and 1.4 μm, respectively[2].
Treatment of the CD8+ T-cell line, TK.1 cells with GW9578 (10 nM-1 μM; for 24 hours) is able to induce a dose-dependent increase in the amount of relative luciferase activity[3].
Treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM; for 2 hours) leads to a significant decrease in IL-2 production compared with control cells[3].
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