Dihydroergocristine (mesylate)
CAS No. : 24730-10-7
(Synonyms: DHEC (mesylate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $160 | In-stock |
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| Cat. No. : | HY-N2319 |
| M.Wt: | 707.84 |
| Formula: | C36H45N5O8S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. In Vitro: Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC50 value of 25?μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability[1]. Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells[1].
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