Abaloparatide


CAS No. : 247062-33-5

(Synonyms: BA 058; BIM 44058)

247062-33-5
Price and Availability of CAS No. : 247062-33-5
Size Price Stock
5mg $170 In-stock
10mg $270 In-stock
25mg $520 In-stock
50mg $780 In-stock
100mg $1170 In-stock
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Cat. No. : HY-108742
M.Wt: 3960.59
Formula: C174H300N56O49
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic)
Introduction of 247062-33-5 :

Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis[1][2]. In Vitro: Abaloparatide (0-100 nM; 40 min) enhances Gs/cAMP signaling and β-arrestin recruitment in MC3T3-E1 cells[1].
Abaloparatide (0-100 nM) efficiently induces PTHR1 internalization in a dose-dependen manner with an EC50 value of 0.8 nM in U2OS Cell[1]. In Vivo: Abaloparatide (20-80 µg/kg; s.c.; daily for 30 days) enhances bone formation and cortical structure in mouse[1].

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