C16-Ceramide
CAS No. : 24696-26-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $49 | In-stock |
| 10mg | $74 | In-stock |
| 25mg | $146 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $360 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100354 |
| M.Wt: | 537.90 |
| Formula: | C34H67NO3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 20 mg/mL (warming;heat to 60°C);DMF : 20 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : < 1 mg/mL (ultrasonic) |
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding[1].
IC50 & Target:p53[1], Apoptosis[2]
In Vitro: C16-Ceramide interacts with p53 within its core domain. p53 forms complex with natural C16-Ceramide in the cell[1].
C16-Ceramide (2.5-50 μM; 0-48 h) strongly decreased HCT116 cell viability in a time- and concentration-dependent manner[2].
C16-Ceramide (12 μM; 48 h) induces apoptosis through Btf (Bcl-2-associated transcription factor) in HCT116 cells[2].
C16-ceramide (12 μM; 0-6 h) and Btf expression up-regulate p53 and BAX expression. C16-ceramide down-regulates Mdm2 expression via Btf[2].
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