Catharanthine
CAS No. : 2468-21-5
(Synonyms: (+)-3,4-Didehydrocoronaridine)
| Size | Price | Stock |
|---|---|---|
| 25mg | $32 | In-stock |
| 50mg | $50 | In-stock |
| 100mg | $72 | In-stock |
| 500mg | $180 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-N0252 |
| M.Wt: | 336.43 |
| Formula: | C21H24N2O2 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ mg/mL;DMSO : ≥ 100 mg/mL |
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity[1][2].
In Vivo:Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) evokes dose-dependent reductions in both BP and HR[1].
Catharanthine (40 mg/kg; ip; single dose) with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h[1].
Catharanthine (20 mg/kg; ip; for 14 consecutive days) increases swimming time and decreases immobility time at D7 or D14 in mice[1].
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