Motexafin gadolinium
CAS No. : 246252-06-2
(Synonyms: PCI 0120; Gadolinium texaphyrin; Gd-Tex)
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| Cat. No. : | HY-16336 |
| M.Wt: | 1148.40 |
| Formula: | C52H72GdN5O14 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Motexafin gadolinium (PCI 0120) is a potent antitumor agent. Motexafin gadolinium is a specific texaphyrin in complex with gadolinium(III). Motexafin gadolinium increases intracellular ROS production. Motexafin gadolinium enhances sensitivity of tumor cells to ionizing radiation[1][2][3].
In Vitro: Motexafin gadolinium (50 µM; 22 h) leads to dichlorofluorescein acetate (DCFA) oxidation in A549 cells[1].
Motexafin gadolinium (100 µM; 4, 12 h) increases intracellular ROS production and apoptosis (24 h) when combined with Zn (100 μM), and ascorbate (100 μM) in Ramos lymphoma cells[2].
Motexafin gadolinium (0.01-100 μM) dose-dependent decrease the expression of p53 protein in HF-1 cells when combined with Zn (100 μM), and ascorbate (100 μM)[2].
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