AL-8810

AL-8810 is a potent and selective antagonist of the PGF _2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The K_i of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG)^{[1][2][3][4][5]}. In Vitro:AL-8810 (0.1, 1, 10 μM, 24 h) can significantly reduce the neuronal cell death of WT mice after OGD-induced injury^[2].
AL-8810 (1, 10 μM, 24 h) promotes the activation of ERK1/2 in HEK 293 and MG-63 cells through epidermal growth factor receptor deactivation mechanism^[3].
In Vivo:AL-8810 (1 or 10 mg/kg, intravenously) reduces ischemic brain injury and neurotoxicity in mice^[2].
AL-8810 (10 mg/kg, intraperitoneal injection) can improve the prognosis after experimental traumatic brain injury in mice^[5].