TRi-1
CAS No. : 246020-68-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $280 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125006 |
| M.Wt: | 328.73 |
| Formula: | C12H9ClN2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
IC50 & Target:IC50: 12 nM (TXNRD1)[1].
In Vitro:TRi-1 (0.679 and 6.79 μM; 6 h) has no effect on cellular glutathione (GSH) concentrations in FaDu cells, efficiently activates JNK and p38 phosphorylation[1].
TRi-1 (2 μM) irreversibly inhibit TXNRD1 in an NADPH-dependent manner[1].
TRi-1 (0.1-10 μM; 0-10 h) increases cellular H2O2 production in cultured FaDu cells in a concentration- and time-dependent manner[1].
TRi-1 (10 nM-100 μM; 48 h) shows cytotoxicity toward cancer cells[1].
In Vivo:TRi-1 (10 mg/kg; i.v.; twice a day for 4 days or 5 mg/kg; i.p.; twice a week for 3 weeks) impaires growth and viability of human tumor xenografts and syngeneic mouse tumors[1].
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