(E)-4-Hydroxycrotonic acid
CAS No. : 24587-49-3
(Synonyms: trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA)
| Size | Price | Stock |
|---|---|---|
| 100mg | $84 | In-stock |
| 250mg | $141 | In-stock |
| 1g | $376 | In-stock |
| 5g | $1319 | In-stock |
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| Cat. No. : | HY-100982 |
| M.Wt: | 102.09 |
| Formula: | C4H6O3 |
| Purity: | >98 % |
| Solubility: |
(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
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