Dipeptide 2
CAS No. : 24587-37-9
(Synonyms: N-Valyltryptophan; Val-Trp)
| Size | Price | Stock |
|---|---|---|
| 1g | $48 | In-stock |
| 5g | $117 | In-stock |
| 25g | $536 | In-stock |
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| Cat. No. : | HY-118060 |
| M.Wt: | 303.36 |
| Formula: | C16H21N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC50 of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats[1].
In Vitro:Dipeptide 2 potently inhibits purified ACE with an IC50 of 10.50 ± 0.97 μM[2].
Dipeptide 2 (12.5-50 μM; 24 h) is non-toxic to HUVECs[2].
Dipeptide 2 (12.5-50 μM; 4 h) reduces intracellular calcium concentration in Ang I-induced HUVECs, promoting vascular smooth muscle relaxation[2].
Dipeptide 2 (12.5-50 μM; 4 h) promotes NO production in Ang I-induced HUVECs, with a 12.9% increase at 50 μM[2].
In Vivo:Dipeptide 2 (10-40 mg/kg; p.o.; once daily; for 12 consecutive days) exerts significant in vivo hypotensive activity in spontaneously hypertensive rats[2].
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