Dexrazoxane
CAS No. : 24584-09-6
(Synonyms: ICRF-187; ADR-529; NSC-169780)
| Size | Price | Stock |
|---|---|---|
| 25mg | $50 | In-stock |
| 50mg | $80 | In-stock |
| 100mg | $130 | In-stock |
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| Cat. No. : | HY-B0581 |
| M.Wt: | 268.27 |
| Formula: | C11H16N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells[1] [2] [3] [4] [5] [6].
In Vitro:Dexrazoxane (0-500 μM; 0-24 h) induces DNA breaks, ATF3 accumulation, DNA damage response and apoptosis in human fibrosarcoma cell line [4].
Dexrazoxane(100 µM; 72 h) inhibits ferroptosis of H9c2 cells by inhibiting HMGB1[5].
In Vivo:Dexrazoxane (8 mg/kg; Intravenous injection; 7 weeks) plays a protective role in rat models of cardiomyopathy induced by doxorubicin (HY-15142)[2].
Dexrazoxane (5-15 mg/kg; Intraperitoneal injection; 3-5 weeks) has antioxidant and anti-inflammatory effects in rodent models of Parkinson's disease[6].
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