5'-Methylthioadenosine
CAS No. : 2457-80-9
(Synonyms: 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine)
| Size | Price | Stock |
|---|---|---|
| 50mg | $36 | In-stock |
| 100mg | $46 | In-stock |
| 250mg | $62 | In-stock |
| 1g | $166 | In-stock |
| 5g | $670 | In-stock |
| 25g | $2345 | Get quote |
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| 100 g | Get quote | |
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| Cat. No. : | HY-16938 |
| M.Wt: | 297.34 |
| Formula: | C11H15N5O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);DMF : 2.5 mg/mL (ultrasonic);H2O : 1 mg/mL (ultrasonic) |
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2]. In Vitro: 5'-Methylthioadenosine protects MTAP+ cells significantly better than MTAP− cells from 6TG (6′-thioguanine) toxicity[3]. In Vivo: The 2FA (2′-fluoroadenine) + MTA (5'-Methylthioadenosine) combination (100 mg/kg MTA; 20 mg/kg 2FA) inhibits tumor growth of four different MTAP− human tumor cell lines in mouse xenograft models[3].
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