LED209
CAS No. : 245342-14-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $31 | In-stock |
| 10mg | $50 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $310 | In-stock |
| 200mg | $445 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-19748 |
| M.Wt: | 383.49 |
| Formula: | C19H17N3O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. LED209 inhibits the binding of signaling molecules to QseC. LED209 has antibacterial activity[1].
In Vitro:LED209 (5 nM, 24 h) decreases biofilm formation in EAEC O104:H4 and several multidrug-resistant clinical isolates of rUTIs[1].
LED209 (7.5-30 μM, 0-80 h) reduces L. pneumophila replication with IC50 values of 1.27 µM and 50.6 µM respectively[2].
LED209 (5 pM) inhibits the binding of signals (norepinephrine) to QseC, preventing QseC autophosphorylation and inhibiting QseC-mediated activation of virulence gene expression[3].
In Vivo:LED209 (20 mg/kg, p.o., a single dose at 30 min prior to intraperitoneal injection of S. Typhimurium) protects mice against S. Typhimurium and F. tularensis murine infections, as well as F. tularensis murine infections (administered orally to mice either 1, 3, 6, 9, or 24 h prior to infection)[1].
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