Lidorestat
CAS No. : 245116-90-9
(Synonyms: IDD-676)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $135 | In-stock |
| 50mg | $200 | In-stock |
| 100mg | $300 | In-stock |
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| Cat. No. : | HY-106198 |
| M.Wt: | 376.35 |
| Formula: | C18H11F3N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation[1][2][3]. IC50 & Target: IC50: 5 nM (Rldose reductase)[1] In Vitro: From in vitro experiments, Lidorestat has a reported IC50 against recombinant human aldose reductase (/h/-ALR2) of 5 μM. Against recombinant human aldehyde reductase (/h/-ALR1), Lidorestat has a reported IC50 of 27,000 μM, yielding a selectivity of /h/-ALR1//h/-ALR2 of 5400:1[1][2]. In Vivo: Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight[1].
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