β,β-Dimethylacrylshikonin

β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth^[1][2][3][4]. In Vitro:β,β-Dimethylacrylshikonin (0-80 μM, 24 or 48 h) inhibits the G2/M phase transition and suppresses TNBC cell proliferation^[3].
β,β-Dimethylacrylshikonin (0-10 μM, 24 h) induces mitochondrial-dependent apoptosis and reduces TNBC cell migration by antagonizing epithelial-mesenchymal transition^[3].
β,β-Dimethylacrylshikonin (0-30 μg/mL, 48 h) reduces Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1 in SGC-7901 cells^[4].
In Vivo:β,β-Dimethylacrylshikonin (0.1% suspension in PBS, applied topically on wounds, daily for 12d) accelerates Hydrocortisone (HY-N0583)-induced impaired wound healing in rats^[2].
β,β-Dimethylacrylshikonin (1 or 2 mg/kg, i.p., on alternate days) suppresses tumor growth in BT-549 xenograft mice model by inhibiting STAT3 phosphorylation^[3].
β,β-Dimethylacrylshikonin (0.5-1.5 mg/kg, i.p.) suppresses tumor growth in MFC gastric xenograft mice model^[4].