L748337
CAS No. : 244192-94-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $252 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $620 | In-stock |
| 100mg | $865 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103211 |
| M.Wt: | 497.61 |
| Formula: | C26H31N3O5S |
| Purity: | >98 % |
| Solubility: | Ethanol : 30 mg/mL (ultrasonic;warming);DMSO : 100 mg/mL (ultrasonic) |
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively[1]. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6[2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases[1][2][3]. In Vitro: L748337 (1 μM) inhibits iNOS expression in B16F10 cells[1]. In Vivo: L-748337 (intraperitoneal injection; 5 mg/kg; beginning 10 days until D18) decreases the growth of melanoma induced by B16F10 cell inoculation and decreases tumor vasculature in mice[1].
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